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The nucleus reuniens is a region of the thalamus midline nuclear group. In the human brain, it is located in the interthalamic adhesion ( massa intermedia). (1983). 9780683014617, Williams & Wilkins. ISBN 9780683014617 It is also known as the medioventral nucleus. (1985). 9781461357049, Springer. ISBN 9781461357049
The nucleus reuniens receives afferent input from a large number of structures, mainly from limbic system and limbic-associated structures. It sends projections to the medial prefrontal cortex, the hippocampus, perirhinal cortex, and entorhinal cortex, although there exist sparse connections to many other afferent structures as well.
The unique medial prefrontal cortex and hippocampal connectivity allows reuniens to regulate neural traffic in this cortical network related to changes in an organism's attentiveness, making reuniens critical to associative learning, memory retrieval, memory generalization, spatial route planning, and resilience to stress.
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